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KBTB4 Rabbit Polyclonal Antibody
KBTB4 Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q9NVX7 |
| Reactivity | Human, Mouse |
| Host | Polyclonal, Rabbit,IgG |
| Clonality | Polyclonal |
| Calculated MW | 59904 Da |
| Gene ID | 55709 |
|---|---|
| Other Names | Kelch repeat and BTB domain-containing protein 4, BTB and kelch domain-containing protein 4, KBTBD4, BKLHD4 |
| Storage Conditions | -20℃ |
| Name | KBTBD4 |
|---|---|
| Synonyms | BKLHD4 |
| Function | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex which targets CoREST corepressor complex components RCOR1, KDM1A/LSD1 and HDAC2 for proteasomal degradation (PubMed:33417871). RCOR1 is likely to be the primary target while degradation of KDM1A and HDAC2 is likely due to their association with RCOR1 (PubMed:33417871). Also targets RCOR3, MIER2 and MIER3 for proteasomal degradation as well as associated proteins ZNF217 and RREB1 (PubMed:36997086). Degradation is dependent on the presence of an ELM2 domain in the target proteins (PubMed:36997086). |
Research Areas
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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Cat# AP93461
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