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CALCOCO2 Rabbit Polyclonal Antibody
CALCOCO2 Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q13137 |
| Reactivity | Rat, Human, Mouse |
| Host | Polyclonal, Rabbit,IgG |
| Clonality | Polyclonal |
| Calculated MW | 52254 Da |
| Gene ID | 10241 |
|---|---|
| Other Names | Calcium-binding and coiled-coil domain-containing protein 2, Antigen nuclear dot 52 kDa protein, Nuclear domain 10 protein NDP52, Nuclear domain 10 protein 52, Nuclear dot protein 52, CALCOCO2, NDP52 {ECO:0000303|PubMed:7540613} |
| Storage Conditions | -20℃ |
| Name | CALCOCO2 |
|---|---|
| Synonyms | NDP52 {ECO:0000303|PubMed:7540613} |
| Function | Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation. Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens such as Salmonella typhimurium upon entry into the cytosol by targeting LGALS8-associated bacteria for autophagy (PubMed:22246324). Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation (PubMed:23022382, PubMed:25771791). Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and/or GABARAPL2, whereas regulation of pathogen-containing autophagosome maturation requires the interaction with MAP3LC3C (PubMed:23022382, PubMed:25771791). May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion (PubMed:17635994). |
| Cellular Location | Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Cytoplasmic vesicle, autophagosome membrane; Peripheral membrane protein. Note=According to PubMed:7540613, localizes to nuclear dots. According to PubMed:9230084 and PubMed:12869526, it is not a nuclear dot-associated protein but localizes predominantly in the cytoplasm with a coarse-grained distribution preferentially close to the nucleus. |
| Tissue Location | Expressed in all tissues tested with highest expression in skeletal muscle and lowest in brain |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a coiled-coil domain-containing protein. The encoded protein functions as a receptor for ubiquitin-coated bacteria and plays an important role in innate immunity by mediating macroautophagy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012],
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