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TMM8A Rabbit Polyclonal Antibody
TMM8A Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q9HCN3 |
| Reactivity | Human, Mouse |
| Host | Polyclonal, Rabbit,IgG |
| Clonality | Polyclonal |
| Calculated MW | 84761 Da |
| Gene ID | 58986 |
|---|---|
| Other Names | Post-GPI attachment to proteins factor 6, 3.1.1.4, GPI processing phospholipase A2, GPI-PLA2, Protein M83, Transmembrane protein 6, Transmembrane protein 8, Transmembrane protein 8A, PGAP6 {ECO:0000303|PubMed:27881714, ECO:0000312|HGNC:HGNC:17205} |
| Storage Conditions | -20℃ |
| Name | PGAP6 {ECO:0000303|PubMed:27881714, ECO:0000312|HGNC:HGNC:17205} |
|---|---|
| Function | Involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchor proteins (GPI-AP). Has phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI. Required for the shedding of the GPI-AP CRIPTO, but not CFC1, at the cell surface. Shedding of CRIPTO modulates Nodal signaling by allowing soluble CRIPTO to act as a Nodal coreceptor on other cells (PubMed:27881714). Also indirectly involved in the translocation of RAC1 from the cytosol to the plasma membrane by maintaining the steady state amount of CAV1-enriched plasma membrane subdomains, stabilizing RAC1 at the plasma membrane (PubMed:27835684). In contrast to myomaker (TMEM8C), has no fusogenic activity (PubMed:26858401). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein |
| Tissue Location | Expressed in pancreas, placenta, spleen, liver, kidney, bone marrow, peripheral blood leukocytes and tonsil |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 385.00
Cat# AP93399
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