RAC3 Antibody
Rabbit mAb
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC |
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Primary Accession | P60763 |
Reactivity | Rat |
Clonality | Monoclonal |
Other Names | Rac1B; RAC3; |
Isotype | Rabbit IgG |
Host | Rabbit |
Calculated MW | 21379 Da |
Dilution | WB 1:500~1:2000 IHC 1:50~1:200 |
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Purification | Affinity-chromatography |
Immunogen | A synthesized peptide derived from human RAC3 |
Description | Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. |
Storage Condition and Buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle. |
Name | RAC3 (HGNC:9803) |
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Function | Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles. Promotes cell adhesion and spreading on fibrinogen in a CIB1 and alpha-IIb/beta3 integrin-mediated manner. |
Cellular Location | Cytoplasm. Endomembrane system. Cell projection, lamellipodium. Cytoplasm, perinuclear region. Cell membrane. Cytoplasm, cytoskeleton. Note=Membrane-associated when activated. Colocalizes with NRBP to endomembranes and at the cell periphery in lamellipodia Colocalized with CIB1 in the perinuclear area and at the cell periphery |
Tissue Location | Highest levels in brain, also detected in heart, placenta and pancreas |
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