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> home > Products > Primary Antibodies > Signal Transduction > phospho-Phospholipase C gamma 1/PLC-gamma-1 (Y1253)
phospho-Phospholipase C gamma 1/PLC-gamma-1 (Y1253)
Rabbit mAb
- SPECIFICATION
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Application 
| WB |
|---|---|
| Primary Accession | P19174 |
| Clonality | Monoclonal |
| Other Names | PLC-148; PLC-II; PLC-gamma1; PLC1; PLCG-1; Phospholipase C-gamma-1; |
| Isotype | Rabbit IgG |
| Host | Rabbit |
| Calculated MW | 148532 Da |
| Dilution | WB 1:500~1:2000 |
|---|---|
| Purification | Affinity-chromatography |
| Immunogen | A synthesized peptide derived from human phospho-Phospholipase C gamma 1/PLC-gamma-1 (Y1253) |
| Description | Plays a role in actin reorganization and cell migration. The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. |
| Storage Condition and Buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle. |
| Name | PLCG1 (HGNC:9065) |
|---|---|
| Synonyms | PLC1 |
| Function | Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, EGFR, FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity). Plays a role in actin reorganization and cell migration (PubMed:17229814). Guanine nucleotide exchange factor that binds the GTPase DNM1 and catalyzes the dissociation of GDP, allowing a GTP molecule to bind in its place, therefore enhancing DNM1-dependent endocytosis (By similarity). |
| Cellular Location | Cell projection, lamellipodium. Cell projection, ruffle. Note=Rapidly redistributed to ruffles and lamellipodia structures in response to epidermal growth factor (EGF) treatment. |
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$ 350.00
$ 175.00
Cat# AP93209
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