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CLIP170 Antibody
Rabbit mAb
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC |
|---|---|
| Primary Accession | P30622 |
| Clonality | Monoclonal |
| Other Names | CLIP; CYLN1; Restin; RSN; |
| Isotype | Rabbit IgG |
| Host | Rabbit |
| Calculated MW | 162246 Da |
| Dilution | WB 1:500~1:2000 IHC 1:50~1:200 |
|---|---|
| Purification | Affinity-chromatography |
| Immunogen | A synthesized peptide derived from human CLIP170 |
| Description | Seems to be a intermediate filament associated protein that links endocytic vesicles to microtubules. |
| Storage Condition and Buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle. |
| Name | CLIP1 |
|---|---|
| Synonyms | CYLN1, RSN |
| Function | Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. |
| Cellular Location | Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, ruffle. Note=Localizes to microtubule plus ends (PubMed:17889670, PubMed:21646404). Localizes preferentially to the ends of tyrosinated microtubules (By similarity). Accumulates in plasma membrane regions with ruffling and protrusions. Associates with the membranes of intermediate macropinocytic vesicles (PubMed:12433698) {ECO:0000250|UniProtKB:Q922J3, ECO:0000269|PubMed:12433698, ECO:0000269|PubMed:17889670, ECO:0000269|PubMed:21646404} |
| Tissue Location | Detected in dendritic cells (at protein level). Highly expressed in the Reed-Sternberg cells of Hodgkin disease |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 350.00
$ 175.00
Cat# AP92910
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