EBF1 Antibody
Rabbit mAb
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application ![]()
| WB |
---|---|
Primary Accession | Q9UH73 |
Clonality | Monoclonal |
Other Names | COE1; EBF; Ebf1; O/E 1; OE1; OLF1; |
Isotype | Rabbit IgG |
Host | Rabbit |
Calculated MW | 64464 Da |
Dilution | WB 1:500~1:1000 |
---|---|
Purification | Affinity-chromatography |
Immunogen | A synthesized peptide derived from human EBF1 |
Description | Transcriptional activator which recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'. |
Storage Condition and Buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle. |
Name | EBF1 |
---|---|
Synonyms | COE1, EBF |
Function | Key pioneer transcription factor of B-cell specification and commitment (PubMed:27807034). Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'. Operates in a transcription factor network to activate B-cell-specific genes and repress genes associated with alternative cell fates. For instance, positively regulates many B- cell specific genes including BCR or CD40 while repressing genes that direct cells into alternative lineages, including GATA3 and TCF7 for the T-cell lineage. In addition to its role during lymphopoiesis, controls the thermogenic gene program in adipocytes during development and in response to environmental cold (By similarity). |
Cellular Location | Nucleus. |

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