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Glutathione Peroxidase 2 Antibody
Rabbit mAb
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC |
|---|---|
| Primary Accession | P18283 |
| Clonality | Monoclonal |
| Other Names | GI GPx; GPRP; GPRP-2; GPx-GI; GPX2; GSHPx 2; GSHPx GI; GSHPx-2; GSHPx-GI; |
| Isotype | Rabbit IgG |
| Host | Rabbit |
| Calculated MW | 21954 Da |
| Dilution | WB 1:500~1:2000 IHC 1:50~1:200 |
|---|---|
| Purification | Affinity-chromatography |
| Immunogen | A synthesized peptide derived from human Glutathione Peroxidase 2 |
| Description | Could play a major role in protecting mammals from the toxicity of ingested organic hydroperoxides. Tert-butyl hydroperoxide, cumene hydroperoxide and linoleic acid hydroperoxide but not phosphatidycholine hydroperoxide, can act as acceptors. |
| Storage Condition and Buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle. |
| Name | GPX2 {ECO:0000303|Ref.9, ECO:0000312|HGNC:HGNC:4554} |
|---|---|
| Function | Catalyzes the reduction of hydroperoxides in a glutathione- dependent manner thus regulating cellular redox homeostasis (PubMed:36608588, PubMed:8428933). Can reduce small soluble hydroperoxides such as H2O2, cumene hydroperoxide and tert-butyl hydroperoxide, as well as several fatty acid-derived hydroperoxides (PubMed:36608588, PubMed:8428933). Cannot reduce phosphatidycholine hydroperoxide (PubMed:8428933). |
| Cellular Location | Cytoplasm, cytosol. |
| Tissue Location | Mostly in liver and gastrointestinal tract, not found in heart or kidney. |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 350.00
$ 175.00
Cat# AP92000
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