DMRT1 Antibody
Rabbit mAb
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application ![]()
| WB, IP |
---|---|
Primary Accession | Q9Y5R6 |
Clonality | Monoclonal |
Other Names | CT154; dmrt1; DMT1; |
Isotype | Rabbit IgG |
Host | Rabbit |
Calculated MW | 39473 Da |
Dilution | WB 1:500~1:2000 IP 1:80 |
---|---|
Purification | Affinity-chromatography |
Immunogen | A synthesized peptide derived from human DMRT1 |
Description | May be required for testis development. |
Storage Condition and Buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle. |
Name | DMRT1 |
---|---|
Synonyms | DMT1 |
Function | Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promotes spermatogonial development by activating spermatogonial differentiation genes, such as SOHLH1. Also plays a key role in postnatal sex maintenance by maintaining testis determination and preventing feminization: represses transcription of female promoting genes such as FOXL2 and activates male-specific genes. May act as a tumor suppressor. May also play a minor role in oogenesis (By similarity). |
Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00070}. |
Tissue Location | Testis-specific. Expressed in prostate cancer (at protein level). |

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