eIF2B epsilon Antibody
Rabbit mAb
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC, ICC |
---|---|
Primary Accession | Q13144 |
Clonality | Monoclonal |
Other Names | CACH; CLE; EIF 2B; EIF2B; EIF2B5; EIF2BE; EIF2Bepsilon; |
Isotype | Rabbit IgG |
Host | Rabbit |
Calculated MW | 80380 Da |
Dilution | WB 1:500~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200 |
---|---|
Purification | Affinity-chromatography |
Immunogen | A synthesized peptide derived from human eIF2B epsilon |
Description | Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. |
Storage Condition and Buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle. |
Name | EIF2B5 |
---|---|
Synonyms | EIF2BE |
Function | Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2) gamma subunit (PubMed:25858979, PubMed:27023709, PubMed:31048492). Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl- initiator methionine tRNA available to the ribosome and consequently global translation is repressed (PubMed:25858979, PubMed:31048492). |
Cellular Location | Cytoplasm, cytosol {ECO:0000250|UniProtKB:P56287} |
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