alpha 1 Antichymotrypsin Antibody
Rabbit mAb
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC, ICC, IP |
---|---|
Primary Accession | P01011 |
Clonality | Monoclonal |
Other Names | SERPINA3; AACT; ACT; Antichymotrypsin; GIG24; GIG25; Serpin A3; SERPINA3; |
Isotype | Rabbit IgG |
Host | Rabbit |
Calculated MW | 47651 Da |
Dilution | WB 1:500~1:1000 IHC 1:100~1:500 ICC/IF 1:50~1:200 IP 1:30 |
---|---|
Purification | Affinity-chromatography |
Immunogen | A synthesized peptide derived from human alpha 1 Antichymotrypsin |
Description | Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2. |
Storage Condition and Buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle. |
Name | SERPINA3 |
---|---|
Synonyms | AACT |
Function | Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2. |
Cellular Location | Secreted. |
Tissue Location | Plasma. Synthesized in the liver. Like the related alpha-1-antitrypsin, its concentration increases in the acute phase of inflammation or infection. Found in the amyloid plaques from the hippocampus of Alzheimer disease brains. |
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