Insulin Receptor R Antibody
Rabbit mAb
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC |
---|---|
Primary Accession | P14616 |
Reactivity | Rat |
Clonality | Monoclonal |
Other Names | INSRR; Insulin receptor related receptor precursor; IR related receptor; IRR; Sirr; |
Isotype | Rabbit IgG |
Host | Rabbit |
Calculated MW | 143720 Da |
Dilution | WB 1:500~1:2000 IHC 1:50~1:200 |
---|---|
Purification | Affinity-chromatography |
Immunogen | A synthesized peptide derived from human Insulin Receptor R |
Description | This receptor probably binds an insulin related protein and has a tyrosine-protein kinase activity. It phosphorylates the insulin receptor substrates IRS-1 and IRS-2. |
Storage Condition and Buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle. |
Name | INSRR |
---|---|
Synonyms | IRR |
Function | Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB. |
Cellular Location | Membrane; Single-pass type I membrane protein. |
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