OGG1 Antibody
Rabbit mAb
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
---|---|
Primary Accession | O15527 |
Clonality | Monoclonal |
Other Names | 8 hydroxyguanine DNA glycosylase; AP lyase; HMMH; HOGG1; MMH; MUTM; N glycosylase; Ogg1; OGH 1; |
Isotype | Rabbit IgG |
Host | Rabbit |
Calculated MW | 38782 Da |
Dilution | WB 1:500~1:2000 |
---|---|
Purification | Affinity-chromatography |
Immunogen | A synthesized peptide derived from human OGG1 |
Description | DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion. |
Storage Condition and Buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle. |
Name | OGG1 |
---|---|
Synonyms | MMH, MUTM, OGH1 |
Function | DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N- methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion. |
Cellular Location | Nucleus, nucleoplasm. Nucleus speckle. Nucleus matrix. Note=Together with APEX1 is recruited to nuclear speckles in UVA-irradiated cells [Isoform 2A]: Mitochondrion. |
Tissue Location | Ubiquitous. |
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