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Axin2 Antibody
Rabbit mAb
- SPECIFICATION
- CITATIONS
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- BACKGROUND
Application 
| WB, IHC, ICC |
|---|---|
| Primary Accession | Q9Y2T1 |
| Reactivity | Rat |
| Clonality | Monoclonal |
| Other Names | Axil; Axin like protein; Axin2; Axis inhibition protein 2; Conductin; |
| Isotype | Rabbit IgG |
| Host | Rabbit |
| Calculated MW | 93558 Da |
| Dilution | WB 1:500~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200 |
|---|---|
| Purification | Affinity-chromatography |
| Immunogen | A synthesized peptide derived from human Axin2 |
| Description | Axin1 (Axis inhibition protein 1) and Axin2 are multidomain scaffold proteins that negatively regulate Wnt signaling. Axin1 interacts with APC, GSK-3β, Dvl, and β-catenin and promotes the GSK-3β-mediated phosphorylation and subsequent degradation of β-catenin .Down-regulates beta-catenin. |
| Storage Condition and Buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle. |
| Name | AXIN2 |
|---|---|
| Function | Inhibitor of the Wnt signaling pathway. Down-regulates beta- catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B. |
| Cellular Location | Cytoplasm. |
| Tissue Location | Expressed in brain and lymphoblast. |
Research Areas
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$ 350.00
Cat# AP91233
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