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STAT5b Antibody
Rabbit mAb
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, ICC, IP |
|---|---|
| Primary Accession | P51692 |
| Reactivity | Rat |
| Clonality | Monoclonal |
| Other Names | Signal transducer and activator of transcription 5B; STA5B; STAT5; Stat5b; Transcription factor STAT5B; |
| Isotype | Rabbit IgG |
| Host | Rabbit |
| Calculated MW | 89866 Da |
| Dilution | WB 1:1000~1:2000 IHC 1:1000~1:2000 ICC/IF 1:1000~1:2000 IP 1:40 |
|---|---|
| Purification | Affinity-chromatography |
| Immunogen | A synthesized peptide derived from human STAT5b |
| Description | Stat5 is activated in response to a wide variety of ligands including IL-2, GM-CSF, growth hormone and prolactin. Stat5 is constitutively active in some leukemic cell types. Phosphorylated Stat5 is found in some endothelial cells treated with IL-3, which suggests its involvement in angiogenesis and cell motility. Stat5a and Stat5b are independently regulated and activated in various cell types. |
| Storage Condition and Buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle. |
| Name | STAT5B |
|---|---|
| Function | Carries out a dual function: signal transduction and activation of transcription (PubMed:29844444). Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription. Positively regulates hematopoietic/erythroid differentiation. |
| Cellular Location | Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation. |
Research Areas
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 350.00
$ 175.00
Cat# AP90880
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