IRS1 Antibody
Rabbit mAb
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC, ICC |
---|---|
Primary Accession | P35568 |
Clonality | Monoclonal |
Other Names | HIRS1; Insulin receptor substrate 1; IRS 1; IRS1; |
Isotype | Rabbit IgG |
Host | Rabbit |
Calculated MW | 131591 Da |
Dilution | WB 1:1000~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200 |
---|---|
Purification | Affinity-chromatography |
Immunogen | A synthesized peptide derived from human IRS1 |
Description | IRS1 is one of the major substrates of the insulin receptor kinase. May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. |
Storage Condition and Buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle. |
Name | IRS1 |
---|---|
Function | May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity). |
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