Cyclin E2 Antibody
Rabbit mAb
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC, FC, ICC |
---|---|
Primary Accession | O96020 |
Clonality | Monoclonal |
Other Names | CCN E2; CCNE 2; CCNE2 protein; CYC E2; CYCE 2; CyclinE2; G1/S specific cyclin E2; |
Isotype | Rabbit IgG |
Host | Rabbit |
Calculated MW | 46757 Da |
Dilution | WB 1:500~1:1000 IHC 1:50~1:200 ICC/IF 1:100~1:500 FC 1:20 |
---|---|
Purification | Affinity-chromatography |
Immunogen | A synthesized peptide derived from human Cyclin E2 |
Description | Cyclin E1 and cyclin E2 can associate with and activate CDK2. Upon DNA damage, upregulation/activation of the CDK inhibitors p21 Waf1/Cip1 and p27 Kip1 prevent cyclin E/CDK2 activation, resulting in G1/S arrest. Essential for the control of the cell cycle at the late G1 and early S phase. |
Storage Condition and Buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle. |
Name | CCNE2 |
---|---|
Function | Essential for the control of the cell cycle at the late G1 and early S phase. |
Cellular Location | Nucleus. |
Tissue Location | According to PubMed:9858585, highest levels of expression in adult testis, thymus and brain. Lower levels in placenta, spleen and colon. Consistently elevated levels in tumor-derived cells compared to non-transformed proliferating cells. According to PubMed:9840927: low levels in thymus, prostate, brain, skeletal muscle, and kidney. Elevated levels in lung. According to PubMed:9840943 highly expressed in testis, placenta, thymus and brain. In a lesser extent in small intestine and colon |
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