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CD68 Antibody
Rabbit mAb
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | P34810 |
| Reactivity | Rat |
| Clonality | Monoclonal |
| Other Names | CD68 antigen; CD68 molecule; Gp110; LAMP4; Macrophage antigen CD68 (microsialin); Macrosialin; SCARD1; Scavenger receptor class D member 1; |
| Isotype | Rabbit IgG |
| Host | Rabbit |
| Calculated MW | 37408 Da |
| Dilution | WB 1:500~1:1000 |
|---|---|
| Purification | Affinity-chromatography |
| Immunogen | A synthesized peptide derived from human CD68 |
| Description | CD68 belongs to a family of acidic, highly glycosylated lysosomal glycoproteins (LGPs) that includes lamp-1 and lamp-2. Play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. |
| Storage Condition and Buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle. |
| Name | CD68 |
|---|---|
| Function | Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells. |
| Cellular Location | [Isoform Short]: Cell membrane; Single-pass type I membrane protein |
| Tissue Location | Highly expressed by blood monocytes and tissue macrophages. Also expressed in lymphocytes, fibroblasts and endothelial cells. Expressed in many tumor cell lines which could allow them to attach to selectins on vascular endothelium, facilitating their dissemination to secondary sites. |
Research Areas
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$ 350.00
Cat# AP90757
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