VAV2 Antibody
Rabbit mAb
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC, ICC, IP |
---|---|
Primary Accession | P52735 |
Reactivity | Rat |
Clonality | Monoclonal |
Other Names | VAV2; Vav 2 oncogene; VAV-2; |
Isotype | Rabbit IgG |
Host | Rabbit |
Calculated MW | 101289 Da |
Dilution | WB 1:5000~1:20000 IHC 1:50~1:200 ICC/IF 1:50~1:200 IP 1:100 |
---|---|
Purification | Affinity-chromatography |
Immunogen | A synthesized peptide derived from human VAV2 |
Description | Vav proteins belong to the Dbl family of guanine nucleotide exchange factors (GEFs) for Rho/Rac small GTPases. The three identified mammalian Vav proteins (Vav1, Vav2 and Vav3) differ in their expression. Vav1 is expressed only in hematopoietic cells and is involved in the formation of the immune synapse. Vav2 and Vav3 are more ubiquitously expressed. |
Storage Condition and Buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle. |
Name | VAV2 |
---|---|
Function | Guanine nucleotide exchange factor for the Rho family of Ras- related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). |
Tissue Location | Widely expressed. |
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