CPT2 Antibody
Rabbit mAb
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC, ICC |
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Primary Accession | P23786 |
Reactivity | Rat |
Clonality | Monoclonal |
Other Names | CPT1; CPT2; IIAE4; CPTASE; |
Isotype | Rabbit IgG |
Host | Rabbit |
Calculated MW | 73777 Da |
Dilution | WB 1:500~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200 |
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Purification | Affinity-chromatography |
Immunogen | A synthesized peptide derived from human CPT2 |
Description | The protein encoded by this gene is a nuclear protein which is transported to the mitochondrial inner membrane. Together with carnitine palmitoyltransferase I, the encoded protein oxidizes long-chain fatty acids in the mitochondria. Defects in this gene are associated with mitochondrial long-chain fatty-acid (LCFA) oxidation disorders. |
Storage Condition and Buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle. |
Name | CPT2 (HGNC:2330) |
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Synonyms | CPT1 |
Function | Involved in the intramitochondrial synthesis of acylcarnitines from accumulated acyl-CoA metabolites (PubMed:20538056, PubMed:24780397). Reconverts acylcarnitines back into the respective acyl-CoA esters that can then undergo beta-oxidation, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Active with medium (C8- C12) and long-chain (C14-C18) acyl-CoA esters (PubMed:20538056). |
Cellular Location | Mitochondrion inner membrane; Peripheral membrane protein; Matrix side |
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