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MTTP Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | P55157 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 99351 Da |
| Antigen Region | 816-842 aa |
| Gene ID | 4547 |
|---|---|
| Other Names | Microsomal triglyceride transfer protein large subunit, MTTP, MTP |
| Target/Specificity | This MTTP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 816-842 amino acids from the C-terminal region of human MTTP. |
| Dilution | WB~~1:1000 IHC-P~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MTTP Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MTTP |
|---|---|
| Synonyms | MTP |
| Function | Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces (PubMed:15897609, PubMed:16478722, PubMed:22236406, PubMed:23475612, PubMed:25108285, PubMed:26224785, PubMed:8876250, PubMed:8939939). Required for the assembly and secretion of plasma lipoproteins that contain apolipoprotein B (PubMed:16478722, PubMed:23475612, PubMed:26224785, PubMed:8876250, PubMed:8939939). May be involved in regulating cholesteryl ester biosynthesis in cells that produce lipoproteins (By similarity). |
| Cellular Location | Endoplasmic reticulum. Golgi apparatus. Note=Colocalizes with P4HB/PDI in the endoplasmic reticulum (PubMed:23475612, PubMed:26224785) |
| Tissue Location | Liver and small intestine. Also found in ovary, testis and kidney. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
MTTP encodes the large subunit of the heterodimeric microsomal triglyceride transfer protein. Protein disulfide isomerase (PDI) completes the heterodimeric microsomal triglyceride transfer protein, which has been shown to play a entral role in lipoprotein assembly. Mutations in MTP can cause abetalipoproteinemia.
References
Dai,K., et.al., Arterioscler. Thromb. Vasc. Biol. 30 (3), 568-574 (2010)
Oliveira,C.P., et.al., J. Gastroenterol. Hepatol. 25 (2), 357-361 (2010)
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