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Nestin Antibody
Rabbit mAb
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC, ICC |
|---|---|
| Primary Accession | P48681 |
| Clonality | Monoclonal |
| Other Names | NES; Nestin; Nbla00170; ESTM 46; NEST; |
| Isotype | Rabbit IgG |
| Host | Rabbit |
| Calculated MW | 177439 Da |
| Dilution | IHC 1:50~1:200 ICC/IF 1:50~1:200 |
|---|---|
| Purification | Affinity-chromatography |
| Immunogen | A synthesized peptide derived from human Nestin |
| Description | May help to regulate cell structure and intracellular processes required for neural cell division and migration. Upon maturation of the brain, nestin expression is quickly down-regulated and replaced by expression of the neurofilament proteins. Because nestin is expressed in both mature and precursor neuronal and glial cells, as well as in the developing brain and in the brain and spinal cord following damage, nestin is widely accepted as a marker of neural stem/progenitor cells. |
| Storage Condition and Buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle. |
| Name | NES |
|---|---|
| Function | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen- stimulated proliferation of neural progenitor cells (By similarity). |
| Tissue Location | CNS stem cells. |
Research Areas
Citations (0)
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Application Protocols
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$ 350.00
$ 175.00
Cat# AP90658
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