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CDC7 Antibody
Rabbit mAb
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC |
|---|---|
| Primary Accession | O00311 |
| Reactivity | Rat |
| Clonality | Monoclonal |
| Other Names | Cell division cycle 7-related protein kinase, EC 2.7.11.1, CDC7-related kinase, HsCdc7, huCdc7, CDC7, CDC7L1; Hsk1 ; CDC7 kinase |
| Isotype | Rabbit IgG |
| Host | Rabbit |
| Calculated MW | 63888 Da |
| Dilution | WB 1:1000~1:2000 FC 1:100 |
|---|---|
| Purification | Affinity-chromatography |
| Immunogen | A synthesized peptide derived from human CDC7 |
| Description | DNA replication in eukaryotic cells is dependent on the phosphorylation of the pre-replicative complex (preRC) at the origin of replication. Two complexes of proteins mediate this event, the cyclin dependent kinase (CDK) complex, and the Cdc7 kinase-ASK complex. Human Cdc7 kinase consists of 574 amino acids with a molecular weight of 55 kDa. The activity of Cdc7 kinase oscillates during cell cycle. The major targets of Cdc7 kinase are proteins that belong to the MCM complex (mini chromosome maintenance proteins). |
| Storage Condition and Buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle. |
| Name | CDC7 (HGNC:1745) |
|---|---|
| Synonyms | CDC7L1 |
| Function | Kinase involved in initiation of DNA replication. Phosphorylates critical substrates that regulate the G1/S phase transition and initiation of DNA replication, such as MCM proteins and CLASPIN. |
| Cellular Location | Nucleus. |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 350.00
$ 175.00
Cat# AP90296
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