CLGN Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application
| FC, IHC-P, WB, E |
---|---|
Primary Accession | O14967 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 70039 Da |
Antigen Region | 309-336 aa |
Gene ID | 1047 |
---|---|
Other Names | Calmegin, CLGN |
Target/Specificity | This CLGN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 309-336 amino acids from the Central region of human CLGN. |
Dilution | WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | CLGN Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CLGN |
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Function | Functions during spermatogenesis as a chaperone for a range of client proteins that are important for sperm adhesion onto the egg zona pellucida and for subsequent penetration of the zona pellucida. Required for normal sperm migration from the uterus into the oviduct. Required for normal male fertility. Binds calcium ions (By similarity). |
Cellular Location | Endoplasmic reticulum membrane; Single-pass type I membrane protein |
Tissue Location | Detected in testis (at protein level). Detected in testis. |
Provided below are standard protocols that you may find useful for product applications.
Background
CLGN probably plays an important role in spermatogenesis. Binds calcium ions.
References
van Lith M., et.al., Mol. Biol. Cell 18:2795-2804(2007).
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