CD20 Antibody
Rabbit mAb
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC, FC |
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Primary Accession | P11836 |
Clonality | Monoclonal |
Other Names | B1; S7; Bp35; CD20; MS4A2; LEU-16; MS4A1 |
Isotype | Rabbit IgG |
Host | Rabbit |
Calculated MW | 33077 Da |
Dilution | WB 1:500~1:2000 IHC 1:50~1:200 FC 1:50~1:200 |
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Purification | Affinity-chromatography |
Immunogen | A synthesized peptide derived from human CD20 |
Description | This protein may be involved in the regulation of B-cell activation and proliferation. CD20 (MS4A1, membrane-spanning 4-domains, subfamily A, member 1) is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. |
Storage Condition and Buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle. |
Name | MS4A1 |
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Synonyms | CD20 |
Function | B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes (PubMed:12920111, PubMed:3925015, PubMed:7684739). Functions as a store-operated calcium (SOC) channel component promoting calcium influx after activation by the B-cell receptor/BCR (PubMed:12920111, PubMed:18474602, PubMed:7684739). |
Cellular Location | Cell membrane; Multi-pass membrane protein. Cell membrane; Lipid-anchor. Note=Constitutively associated with membrane rafts. |
Tissue Location | Expressed on B-cells. |
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