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> home > Products > Primary Antibodies > Antibody Collections > Loading Control > beta Actin Mouse Monoclonal Antibody
beta Actin Mouse Monoclonal Antibody
Mouse mAb
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Application 
| WB |
|---|---|
| Primary Accession | P60709 |
| Reactivity | Rat, Rice |
| Clonality | Monoclonal |
| Other Names | ACTIN; ACTB; BETA-ACTIN; beta actin; actin beta; |
| Isotype | Mouse IgG2b |
| Host | Mouse |
| Calculated MW | 41737 Da |
| Dilution | WB 1:3000~1:10000 |
|---|---|
| Purification | Affinity-chromatography |
| Immunogen | A synthesized peptide derived from human beta Actin |
| Description | beta-Actin is one of six different actin isoforms that have been identified. The actin molecules found in cells of various species and tissues tend to be very similar in their immunological and physical properties. Therefore, Antibodies against beta-Actin are useful as loading controls for Western Blotting. However it should be noted that levels of beta-Actin may not be stable in certain cells. For example, expression of beta-Actin in adipose tissue is very low and therefore it should not be used as loading control for these tissues. |
| Storage Condition and Buffer | Mouse IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle. |
| Name | ACTB |
|---|---|
| Function | Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (PubMed:25255767, PubMed:29581253). Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (PubMed:29581253). In addition to their role in the cytoplasmic cytoskeleton, G- and F- actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (PubMed:29925947). Part of the ACTR1A/ACTB filament around which the dynactin complex is built. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). |
| Cellular Location | Cytoplasm, cytoskeleton. Nucleus Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. |
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$ 350.00
$ 175.00
Cat# AP90038
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