DAB1 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, WB, E |
---|---|
Primary Accession | O75553 |
Other Accession | Q8CJH2, P97318, Q9BGX5 |
Reactivity | Human, Mouse |
Predicted | Monkey, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 63775 Da |
Antigen Region | 189-216 aa |
Gene ID | 1600 |
---|---|
Other Names | Disabled homolog 1, DAB1 |
Target/Specificity | This DAB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 189-216 amino acids from the Central region of human DAB1. |
Dilution | WB~~1:1000 IHC-P~~1:50~100 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | DAB1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | DAB1 |
---|---|
Function | Signaling adapter of the reelin-mediated signaling pathway, which regulates the migration and differentiation of postmitotic neurons during brain development. Mediates intracellular transduction of Reelin signaling following reelin (RELN)-binding to its receptor: acts by docking proteins through its phosphotyrosine residues and PID domain. |
Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:P97318}. |
Tissue Location | Mainly expressed in brain. |
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Provided below are standard protocols that you may find useful for product applications.
Background
DAB1 is adapter molecule functioning in neural development. It may regulate SIAH1 activity (By similarity).
References
Ranganathan S., et.al., J. Biol. Chem. 279:40536-40544(2004).
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