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ADAMTS18 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 2
- PROTOCOLS
- BACKGROUND
Application 
| FC, WB, IHC-P, E |
|---|---|
| Primary Accession | Q8TE60 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 135167 Da |
| Antigen Region | 1066-1095 aa |
| Gene ID | 170692 |
|---|---|
| Other Names | A disintegrin and metalloproteinase with thrombospondin motifs 18, ADAM-TS 18, ADAM-TS18, ADAMTS-18, 3424-, ADAMTS18, ADAMTS21 |
| Target/Specificity | This ADAMTS18 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1066-1095 amino acids from the C-terminal region of human ADAMTS18. |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ADAMTS18 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ADAMTS18 |
|---|---|
| Synonyms | ADAMTS21 |
| Cellular Location | Secreted, extracellular space, extracellular matrix |
| Tissue Location | Expressed in fetal lung, liver, and kidney and in adult brain, prostate, submaxillary gland, and endothelium |
Provided below are standard protocols that you may find useful for product applications.
Background
ADAMTS18 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. This protein has a high sequence similarity to the protein encoded by gene ADAMTS16, another family member. It is thought to function as a tumor suppressor.
References
Zeng,W., et.al., Biochim. Biophys. Acta 1760 (3), 517-524 (2006)
Jin,H., et.al., Oncogene 26 (53), 7490-7498 (2007)
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