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SELENBP1 Antibody (C-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - SELENBP1 Antibody (C-term) AP8869b
    Western blot analysis of SELENBP1 Antibody (C-term) (Cat. #AP8869b) in HL-60 cell line lysates (35ug/lane). SELENBP1 (arrow) was detected using the purified Pab.
    detail
  • WB - SELENBP1 Antibody (C-term) AP8869b
    Western blot analysis of SELENBP1 Antibody (C-term) (Cat. #AP8869b) in mouse lung tissue lysates (35ug/lane). SELENBP1 (arrow) was detected using the purified Pab.
    detail
  • WB - SELENBP1 Antibody (C-term) AP8869b
    Western blot analysis of SELENBP1 (arrow) using rabbit polyclonal SELENBP1 Antibody (C-term) (Cat. #AP8869b). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the SELENBP1 gene.
    detail
  • FC - SELENBP1 Antibody (C-term) AP8869b
    SELENBP1 Antibody (C-term) (Cat. #AP8869b) flow cytometric analysis of HL-60 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, FC, E
Primary Accession Q13228
Other Accession NP_003935
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 52391 Da
Antigen Region 317-344 aa
Additional Information
Gene ID 8991
Other Names Selenium-binding protein 1, 56 kDa selenium-binding protein, SBP56, SP56, SELENBP1, SBP
Target/Specificity This SELENBP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 317-344 amino acids from the C-terminal region of human SELENBP1.
Dilution WB~~1:1000
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSELENBP1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SELENBP1
Synonyms SBP
Function Catalyzes the oxidation of methanethiol, an organosulfur compound known to be produced in substantial amounts by gut bacteria (PubMed:29255262). Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport (By similarity).
Cellular Location Nucleus. Cytoplasm, cytosol Membrane {ECO:0000250|UniProtKB:Q8VIF7}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8VIF7}. Note=May associate with Golgi membrane (By similarity). May associate with the membrane of autophagosomes (By similarity). {ECO:0000250|UniProtKB:Q8VIF7}
Tissue Location Widely expressed. Highly expressed in liver, lung, colon, prostate, kidney and pancreas. In brain, present both in neurons and glia (at protein level). Down-regulated in lung adenocarcinoma, colorectal carcinoma and ovarian cancer. Two-fold up-regulated in brain and blood from schizophrenia patients.
Research Areas
Citations (0)
citation

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Background

SELENBP1 is the selenium-binding protein family. Selenium is an essential nutrient that exhibits potent anticarcinogenic properties, and deficiency of selenium may cause certain neurologic diseases. It has been proposed that the effects of selenium in preventing cancer and neurologic diseases may be mediated by selenium-binding proteins.

References

Kanazawa,T.,et.al., Schizophr. Res. 113 (2-3), 268-272 (2009)

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$ 182.50
$ 70.00
Cat# AP8869b
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