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> home > Products > Primary Antibodies > Antibody Collections > Catalog Updated > SOCS1 Antibody (N-term)
SOCS1 Antibody (N-term)
Purified Rabbit Polyclonal Antibody (Pab)
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- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, IF, IHC-P, E |
|---|---|
| Primary Accession | O15524 |
| Reactivity | Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 23551 Da |
| Antigen Region | 35-66 aa |
| Gene ID | 8651 |
|---|---|
| Other Names | Suppressor of cytokine signaling 1, SOCS-1, JAK-binding protein, JAB, STAT-induced STAT inhibitor 1, SSI-1, Tec-interacting protein 3, TIP-3, SOCS1, SSI1, TIP3 |
| Target/Specificity | This SOCS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 35-66 amino acids from the N-terminal region of human SOCS1. |
| Dilution | IF~~1:10~50 WB~~1:2000 IHC-P~~1:10~50 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SOCS1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SOCS1 |
|---|---|
| Synonyms | SSI1, TIP3 {ECO:0000303|PubMed:9341160} |
| Function | Essential negative regulator of type I and type II interferon (IFN) signaling, as well as that of other cytokines, including IL2, IL4, IL6 and leukemia inhibitory factor (LIF) (PubMed:32499645, PubMed:33087723). Downregulates cytokine signaling by inhibiting the JAK/STAT signaling pathway. Acts by binding to JAK proteins and to IFNGR1 and inhibiting their kinase activity. In vitro, suppresses Tec protein-tyrosine activity (PubMed:9341160). Regulates IFN-gamma (IFNG)- mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:11278610, PubMed:11313480). |
| Cellular Location | Nucleus. Cytoplasmic vesicle. Note=Detected in perinuclear cytoplasmic vesicles upon interaction with FGFR3 |
| Tissue Location | Expressed in all tissues with high expression in spleen, small intestine and peripheral blood leukocytes |
Research Areas
Citations ( 0 )
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
SOCS1 is a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling(SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling.
References
Starr,R.,et.al., Nature 387 (6636), 917-921 (1997) Minamoto,S., et.al., Biochem. Biophys. Res. Commun. 237 (1), 79-83 (1997)
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$ 182.50
$ 70.00
Cat# AP8790A
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