CD24 Antibody (N-Term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, FC, IHC-P, E |
---|---|
Primary Accession | P25063 |
Other Accession | P24807, NP_037362 |
Reactivity | Human |
Predicted | Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 8083 Da |
Antigen Region | 1-30 aa |
Gene ID | 100133941 |
---|---|
Other Names | Signal transducer CD24, Small cell lung carcinoma cluster 4 antigen, CD24, CD24, CD24A |
Target/Specificity | This CD24 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human CD24. |
Dilution | WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | CD24 Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CD24 |
---|---|
Synonyms | CD24A |
Function | May have a pivotal role in cell differentiation of different cell types. Signaling could be triggered by the binding of a lectin- like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Modulates B-cell activation responses. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells (PubMed:11313396). In association with SIGLEC10 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90. Plays a role in the control of autoimmunity (By similarity). |
Cellular Location | Cell membrane; Lipid-anchor, GPI-anchor. |
Tissue Location | B-cells. Expressed in a number of B-cell lines including P32/ISH and Namalwa. Expressed in erythroleukemia cell and small cell lung carcinoma cell lines. Also expressed on the surface of T-cells. |
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Provided below are standard protocols that you may find useful for product applications.
Background
CD24 is a sialoglycoprotein that is expressed on mature granulocytes and in many B cells. This protein is anchored via a glycosyl phosphatidylinositol (GPI) link to the cell surface.
References
Kay,R., et.al., J. Immunol. 147 (4), 1412-1416 (1991)
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