ANO5 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 2
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, WB, E |
---|---|
Primary Accession | Q75V66 |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 107188 Da |
Antigen Region | 792-819 aa |
Gene ID | 203859 |
---|---|
Other Names | Anoctamin-5, Gnathodiaphyseal dysplasia 1 protein, Transmembrane protein 16E, ANO5, GDD1, TMEM16E |
Target/Specificity | This ANO5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 792-819 amino acids from the C-terminal region of human ANO5. |
Dilution | WB~~1:1000 IHC-P~~1:50~100 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | ANO5 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ANO5 |
---|---|
Synonyms | GDD1, TMEM16E |
Function | Plays a role in plasma membrane repair in a process involving annexins (PubMed:33496727). Does not exhibit calcium-activated chloride channel (CaCC) activity. |
Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Colocalized with CALR/calreticulin (PubMed:15124103). Shows an intracellular localization according to PubMed:22075693. |
Tissue Location | Highly expressed in brain, heart, kidney, lung, and skeletal muscle. Weakly expressed in bone marrow, fetal liver, placenta, spleen, thymus, osteoblasts and periodontal ligament cells |
Provided below are standard protocols that you may find useful for product applications.
Background
ANO5 is a member of the anoctamin family of transmembrane proteins. This protein is likely a calcium activated chloride channel.
References
Katoh,M. et.al., Am. J. Hum. Genet. 75 (5), 927-928 (2004)
Tsutsumi,S., et.al., Am. J. Hum. Genet. 74 (6), 1255-1261 (2004)
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