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HK3 (Hexokinase III) Antibody (N-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P52790 |
| Other Accession | NP_002106 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 99025 Da |
| Antigen Region | 1-30 aa |
| Gene ID | 3101 |
|---|---|
| Other Names | Hexokinase-3, Hexokinase type III, HK III, HK3 |
| Target/Specificity | This HK3 (Hexokinase III) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human HK3 (Hexokinase III). |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | HK3 (Hexokinase III) Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | HK3 (HGNC:4925) |
|---|---|
| Function | Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D- fructose 6-phosphate, respectively) (PubMed:8717435). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (PubMed:8717435). |
Provided below are standard protocols that you may find useful for product applications.
Background
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, thus committing glucose to the glycolytic pathway. This gene encodes hexokinase 3. Similar to hexokinases 1 and 2, this allosteric enzyme is inhibited by its product glucose-6-phosphate.
References
Sui, D., et al., Arch. Biochem. Biophys. 382(2):262-274 (2000).
Lowes, W., et al., Biochim. Biophys. Acta 1379(1):134-142 (1998).
Furuta, H., et al., Genomics 36(1):206-209 (1996).
Palma, F., et al., Mol. Cell. Biochem. 155(1):23-29 (1996).
Colosimo, A., et al., Cytogenet. Cell Genet. 74(3):187-188 (1996).
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