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RPS6KB2 Antibody

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - RPS6KB2 Antibody AP8009e
    Western blot analysis of RPS6KB2 Antibody (Cat. #AP8009e) in K562 cell line lysates (35ug/lane). RPS6KB2 (arrow) was detected using the purified Pab.
    detail
  • IHC-P - RPS6KB2 Antibody AP8009e
    Formalin-fixed and paraffin-embedded mouse brain tissue reacted with RPS6KB2 Antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
    detail
  • FC - RPS6KB2 Antibody AP8009e
    RPS6KB2 Antibody (Cat. #AP8009e) flow cytometry analysis of K562 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
FC, IHC-P, WB, E
Primary Accession Q9UBS0
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 53455 Da
Additional Information
Gene ID 6199
Other Names Ribosomal protein S6 kinase beta-2, S6K-beta-2, S6K2, 70 kDa ribosomal protein S6 kinase 2, P70S6K2, p70-S6K 2, S6 kinase-related kinase, SRK, Serine/threonine-protein kinase 14B, p70 ribosomal S6 kinase beta, S6K-beta, p70 S6 kinase beta, p70 S6K-beta, p70 S6KB, p70-beta, RPS6KB2, STK14B
Target/Specificity This RPS6KB2 antibody is generated from rabbits immunized with human RPS6KB2 recombinant protein.
Dilution WB~~1:1000
IHC-P~~1:50~100
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsRPS6KB2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RPS6KB2
Synonyms STK14B
Function Phosphorylates specifically ribosomal protein S6 (PubMed:29750193). Seems to act downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression in an alternative pathway regulated by MEAK7 (PubMed:29750193).
Cellular Location Cytoplasm. Nucleus.
Research Areas
Citations (0)
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Background

RPS6KB2 is a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates the S6 ribosomal protein and eucaryotic translation initiation factor 4B. Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation.

References

Strausberg, R.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99(26):16899-16903 (2002).
Lee-Fruman, K.K., et al., Oncogene 18(36):5108-5114 (1999).
Saitoh, M., et al., Biochem. Biophys. Res. Commun. 253(2):470-476 (1998).
Gout, I., et al., J. Biol. Chem. 273(46):30061-30064 (1998).

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$ 182.50
$ 70.00
Cat# AP8009e
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