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hnRNP C1/C2 Rabbit mAb
- SPECIFICATION
- CITATIONS
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- BACKGROUND
Application 
| WB, IHC-P, FC, IP, ICC |
|---|---|
| Primary Accession | P07910 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Monoclonal Antibody |
| Calculated MW | 33670 Da |
| Gene ID | 3183 |
|---|---|
| Other Names | HNRNPC |
| Dilution | WB~~1/500-1/1000 |
| Format | Liquid |
| Name | HNRNPC |
|---|---|
| Synonyms | HNRPC |
| Function | Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles (PubMed:8264621). Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules (PubMed:12509468, PubMed:16010978, PubMed:7567451, PubMed:8264621). Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides (PubMed:8264621). May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing (PubMed:25719671). |
| Cellular Location | Nucleus. Note=Component of ribonucleosomes |
Research Areas
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 350.00
Cat# AP78972
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