Bim Rabbit mAb
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, FC, IP, ICC |
---|---|
Primary Accession | O43521 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Monoclonal Antibody |
Calculated MW | 22171 Da |
Gene ID | 10018 |
---|---|
Other Names | BCL2L11 |
Dilution | WB~~1/500-1/1000 |
Format | Liquid |
Name | BCL2L11 |
---|---|
Synonyms | BIM |
Function | Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a caspase- mediated pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis. |
Cellular Location | Endomembrane system; Peripheral membrane protein. Note=Associated with intracytoplasmic membranes. [Isoform BimL]: Mitochondrion. [Isoform Bim-alpha1]: Mitochondrion. |
Tissue Location | Isoform BimEL, isoform BimL and isoform BimS are the predominant isoforms and are widely expressed with tissue-specific variation. Isoform Bim-gamma is most abundantly expressed in small intestine and colon, and in lower levels in spleen, prostate, testis, heart, liver and kidney. |
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