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PUMA Rabbit mAb
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- CITATIONS
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- BACKGROUND
Application 
| WB, IHC-P, FC, ICC |
|---|---|
| Primary Accession | Q9BXH1 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Monoclonal Antibody |
| Calculated MW | 20532 Da |
| Gene ID | 27113 |
|---|---|
| Other Names | BBC3 |
| Dilution | WB~~1/500-1/1000 |
| Format | Liquid |
| Name | BBC3 |
|---|---|
| Synonyms | PUMA |
| Function | Essential mediator of p53/TP53-dependent and p53/TP53- independent apoptosis (PubMed:11463391, PubMed:23340338). Promotes partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53, releasing the bound p53/TP53 to induce apoptosis (PubMed:23340338). Regulates ER stress-induced neuronal apoptosis (By similarity). |
| Cellular Location | Mitochondrion Note=Localized to the mitochondria in order to induce cytochrome c release |
| Tissue Location | Ubiquitously expressed. |
Research Areas
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