Phospho-ErbB3 (Tyr1222) Rabbit mAb
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application ![]()
| WB, IP, ICC |
---|---|
Primary Accession | P21860 |
Reactivity | Human |
Host | Rabbit |
Clonality | Monoclonal Antibody |
Calculated MW | 148098 Da |
Gene ID | 2065 |
---|---|
Other Names | ERBB3 |
Dilution | WB~~1/500-1/1000 |
Format | Liquid |
Name | ERBB3 |
---|---|
Synonyms | HER3 |
Function | Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778). May also be activated by CSPG5 (PubMed:15358134). Involved in the regulation of myeloid cell differentiation (PubMed:27416908). |
Cellular Location | [Isoform 1]: Cell membrane; Single-pass type I membrane protein |
Tissue Location | Epithelial tissues and brain. |

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