HIRA Rabbit mAb
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, FC, IP, ICC |
---|---|
Primary Accession | P54198 |
Reactivity | Human |
Host | Rabbit |
Clonality | Monoclonal Antibody |
Calculated MW | 111835 Da |
Gene ID | 7290 |
---|---|
Other Names | HIRA |
Dilution | WB~~1/500-1/1000 |
Format | Liquid |
Name | HIRA |
---|---|
Synonyms | DGCR1, HIR, TUPLE1 |
Function | Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. |
Cellular Location | Nucleus. Nucleus, PML body. Note=Primarily, though not exclusively, localized to the nucleus. Localizes to PML bodies immediately prior to onset of senescence |
Tissue Location | Expressed at high levels in kidney, pancreas and skeletal muscle and at lower levels in brain, heart, liver, lung, and placenta. |
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