SARS Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, WB, E |
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Primary Accession | P49591 |
Other Accession | Q6P799, P26638, Q4R4U9, P26636, Q9GMB8, P13642 |
Reactivity | Human |
Predicted | Bovine, Hamster, Monkey, Mouse, Rabbit, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 58777 Da |
Antigen Region | 394-422 aa |
Gene ID | 6301 |
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Other Names | Serine--tRNA ligase, cytoplasmic, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase, SARS, SERS |
Target/Specificity | This SARS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 394-422 amino acids from the C-terminal region of human SARS. |
Dilution | WB~~1:1000 IHC-P~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | SARS Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SARS1 (HGNC:10537) |
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Synonyms | SARS, SERS |
Function | Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser) (PubMed:22353712, PubMed:24095058, PubMed:26433229, PubMed:28236339, PubMed:34570399, PubMed:36041817, PubMed:9431993). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (PubMed:26433229, PubMed:28236339, PubMed:34570399, PubMed:9431993). In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC (PubMed:24940000). Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys- 16' (H4K16). Thereby, inhibits the production of VEGFA and sprouting angiogenesis mediated by VEGFA (PubMed:19423847, PubMed:19423848, PubMed:24940000). |
Cellular Location | Cytoplasm. Nucleus Note=Predominantly cytoplasmic, but a minor proportion is also found in the nucleus. |
Tissue Location | Brain.. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Seryl-tRNA synthetase belongs to the class II amino-acyl tRNA family. This enzyme catalyzes the transfer of L-serine to tRNA (Ser) and is related to bacterial and yeast counterparts.
References
Shimada,N., J. Biol. Chem. 276 (50), 46770-46778 (2001)
Shah,Z.H., Hum. Mutat. 17 (5), 433-434 (2001)
Heckl,M., FEBS Lett. 427 (3), 315-319 (1998)
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