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PRKCDBP Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q969G5 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 27701 Da |
| Antigen Region | 113-144 aa |
| Gene ID | 112464 |
|---|---|
| Other Names | Protein kinase C delta-binding protein, Cavin-3, Serum deprivation response factor-related gene product that binds to C-kinase, hSRBC, PRKCDBP, SRBC |
| Target/Specificity | This PRKCDBP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 113-144 amino acids from the Central region of human PRKCDBP. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PRKCDBP Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CAVIN3 (HGNC:9400) |
|---|---|
| Synonyms | PRKCDBP, SRBC |
| Function | Regulates the traffic and/or budding of caveolae (PubMed:19262564). Plays a role in caveola formation in a tissue- specific manner. Required for the formation of caveolae in smooth muscle but not in the lung and heart endothelial cells. Regulates the equilibrium between cell surface-associated and cell surface- dissociated caveolae by promoting the rapid release of caveolae from the cell surface. Plays a role in the regulation of the circadian clock. Modulates the period length and phase of circadian gene expression and also regulates expression and interaction of the core clock components PER1/2 and CRY1/2 (By similarity). |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q91VJ2}. Membrane, caveola. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q91VJ2}. Note=Localizes in the caveolae in a caveolin-dependent manner. |
| Tissue Location | Skeletal muscle, liver, stomach, lung, kidney and heart (at protein level). Strongly expressed in mammary and epithelial cells. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
PRKCDBP was identified as a binding protein of the protein kinase C, delta (PRKCD). The expression of this protein in cultured cell lines is strongly induced by serum starvation, and was found to be down-regulated in various cancer cell lines, suggesting the possible tumor suppressor function of this protein.
References
Lee,J.H., Int. J. Cancer 122 (7), 1573-1584 (2008)
Zochbauer-Muller,S., Oncogene 24 (41), 6249-6255 (2005)
Xu,X.L., Cancer Res. 61 (21), 7943-7949 (2001)
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