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WBP2 Antibody (N-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | Q969T9 |
| Other Accession | Q8R478, P97765 |
| Reactivity | Human |
| Predicted | Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 28087 Da |
| Antigen Region | 19-47 aa |
| Gene ID | 23558 |
|---|---|
| Other Names | WW domain-binding protein 2, WBP-2, WBP2 |
| Target/Specificity | This WBP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 19-47 amino acids from the N-terminal region of human WBP2. |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | WBP2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | WBP2 (HGNC:12738) |
|---|---|
| Function | Acts as a transcriptional coactivator of estrogen and progesterone receptors (ESR1 and PGR) upon hormone activation (PubMed:16772533). In presence of estrogen, binds to ESR1-responsive promoters (PubMed:16772533). Synergizes with YAP1 to enhance PGR activity (PubMed:16772533). Modulates expression of post-synaptic scaffolding proteins via regulation of ESR1, ESR2 and PGR (By similarity). |
| Cellular Location | Cytoplasm. Nucleus. Note=Translocates from cytoplasm to nucleus when phosphorylated. |
| Tissue Location | Ubiquitous. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The globular WW domain is composed of 38 to 40 semiconserved amino acids shared by proteins of diverse functions including structural, regulatory, and signaling proteins. The domain is involved in mediating protein-protein interactions through the binding of polyproline ligands. WBP2 is a WW domain binding protein, which binds to the WW domain of Yes kinase-associated protein by its PY motifs. The function of this protein has not been determined.
References
Dhananjayan,S.C., Mol. Endocrinol. 20 (10), 2343-2354 (2006)
Nitsch,R., Biochem. J. 377 (PT 3), 553-560 (2004)
Jolliffe,C.N., Biochem. J. 351 PT 3, 557-565 (2000)
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