Prothrombin Rabbit mAb
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IP |
---|---|
Primary Accession | P00734 |
Reactivity | Human |
Host | Rabbit |
Clonality | Monoclonal Antibody |
Calculated MW | 70037 Da |
Gene ID | 2147 |
---|---|
Other Names | F2 |
Dilution | WB~~1/500-1/1000 |
Format | Liquid |
Name | F2 |
---|---|
Function | Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing. Thrombin triggers the production of pro-inflammatory cytokines, such as MCP-1/CCL2 and IL8/CXCL8, in endothelial cells (PubMed:30568593, PubMed:9780208). |
Cellular Location | Secreted, extracellular space. |
Tissue Location | Expressed by the liver and secreted in plasma. |
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