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CAV1 Antibody (N-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| FC, IHC-P, WB, E |
|---|---|
| Primary Accession | Q03135 |
| Other Accession | P41350, Q09YN6, Q6RVA9, P49817, P79132, Q2QLB0, Q6B3Y2 |
| Reactivity | Human |
| Predicted | Bovine, Horse, Mouse, Pig, Rabbit, Rat, Sheep |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 20472 Da |
| Antigen Region | 2-30 aa |
| Gene ID | 857 |
|---|---|
| Other Names | Caveolin-1, CAV1, CAV |
| Target/Specificity | This CAV1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2-30 amino acids from the N-terminal region of human CAV1. |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CAV1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CAV1 |
|---|---|
| Synonyms | CAV |
| Function | May act as a scaffolding protein within caveolar membranes (PubMed:11751885). Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (PubMed:19262564). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (PubMed:17287217). Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (By similarity). Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (PubMed:25893292). Binds 20(S)- hydroxycholesterol (20(S)-OHC) (By similarity). |
| Cellular Location | Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Membrane raft. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:P33724} Note=Colocalized with DPP4 in membrane rafts. Potential hairpin-like structure in the membrane. Membrane protein of caveolae |
| Tissue Location | Skeletal muscle, liver, stomach, lung, kidney and heart (at protein level). Expressed in the brain |
Provided below are standard protocols that you may find useful for product applications.
Background
The scaffolding protein CAV1 is the main component of the caveolae plasma membranes found in most cell types. This protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The CAV1 gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 MAP kinase cascade.
References
Smith,J.L.,J. Virol. 82 (19), 9505-9512 (2008)
Zhong,Y., J. Neurosci. 28 (31), 7788-7796 (2008)
Di Vizio,D., Cell Cycle 7 (14), 2257-2267 (2008)
Lee,H., J. Biol. Chem. 276 (37), 35150-35158 (2001)
Schlegel,A., J. Biol. Chem. 276 (6), 4398-4408 (2001)
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