CDC5 Rabbit mAb
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, ICC |
---|---|
Primary Accession | Q99459 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Monoclonal Antibody |
Calculated MW | 92251 Da |
Gene ID | 988 |
---|---|
Other Names | CDC5L |
Dilution | WB~~1/500-1/1000 |
Format | Liquid |
Name | CDC5L |
---|---|
Synonyms | KIAA0432, PCDC5RP |
Function | DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays a role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes (PubMed:11991638, PubMed:20176811, PubMed:28076346, PubMed:28502770, PubMed:29301961, PubMed:29360106, PubMed:29361316, PubMed:30705154, PubMed:30728453). Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR) (PubMed:20176811). As a component of the minor spliceosome, involved in the splicing of U12- type introns in pre-mRNAs (Probable). |
Cellular Location | Nucleus. Nucleus speckle. Cytoplasm Note=May shuttle between cytoplasm and nucleus |
Tissue Location | Ubiquitously expressed in both fetal and adult tissues. |
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