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> home > Products > Primary Antibodies > Antibody Collections > Phospho Antibodies > Phospho-SHP2 (Tyr542) Rabbit mAb
Phospho-SHP2 (Tyr542) Rabbit mAb
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Application 
| WB, IP, ICC |
|---|---|
| Primary Accession | Q06124 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Monoclonal Antibody |
| Calculated MW | 68011 Da |
| Gene ID | 5781 |
|---|---|
| Other Names | PTPN11 |
| Dilution | WB~~1/500-1/1000 |
| Format | Liquid |
| Name | PTPN11 |
|---|---|
| Synonyms | PTP2C, SHPTP2 |
| Function | Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus (PubMed:10655584, PubMed:18559669, PubMed:18829466, PubMed:26742426, PubMed:28074573). Positively regulates MAPK signal transduction pathway (PubMed:28074573). Dephosphorylates GAB1, ARHGAP35 and EGFR (PubMed:28074573). Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulation of its RhoA binding activity (PubMed:18559669). Dephosphorylates CDC73 (PubMed:26742426). Dephosphorylates SOX9 on tyrosine residues, leading to inactivate SOX9 and promote ossification (By similarity). Dephosphorylates tyrosine-phosphorylated NEDD9/CAS-L (PubMed:19275884). |
| Cellular Location | Cytoplasm. Nucleus |
| Tissue Location | Widely expressed, with highest levels in heart, brain, and skeletal muscle. |
Research Areas
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$ 350.00
Cat# AP77317
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