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Thioredoxin Interacting Protein Rabbit mAb
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, FC, ICC |
|---|---|
| Primary Accession | Q9H3M7 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Monoclonal Antibody |
| Calculated MW | 43661 Da |
| Gene ID | 10628 |
|---|---|
| Other Names | TXNIP |
| Format | Liquid |
| Name | TXNIP |
|---|---|
| Synonyms | VDUP1 |
| Function | May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability (PubMed:17603038). Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm (By similarity). Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest (PubMed:12821938). Required for the maturation of natural killer cells (By similarity). Acts as a suppressor of tumor cell growth (PubMed:18541147). Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1) (PubMed:21460850). |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q8BG60}. |
Citations (0)
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Application Protocols
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$ 385.00
Cat# AP76980
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