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Calpain 1 Rabbit mAb
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, FC, ICC |
|---|---|
| Primary Accession | P07384 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Monoclonal Antibody |
| Calculated MW | 81890 Da |
| Gene ID | 823 |
|---|---|
| Other Names | CAPN1 |
| Dilution | WB~~1/500-1/1000 |
| Format | Liquid |
| Name | CAPN1 (HGNC:1476) |
|---|---|
| Synonyms | CANPL1 |
| Function | Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction (PubMed:19617626, PubMed:21531719, PubMed:2400579). Proteolytically cleaves CTBP1 at 'Asn-375', 'Gly-387' and 'His-409' (PubMed:23707407). Cleaves and activates caspase-7 (CASP7) (PubMed:19617626). |
| Cellular Location | Cytoplasm. Cell membrane. Note=Translocates to the plasma membrane upon Ca(2+) binding. In granular keratinocytes and in lower corneocytes, colocalizes with FLG and FLG2 (PubMed:21531719) |
| Tissue Location | Ubiquitous. |
Research Areas
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$ 385.00
Cat# AP76967
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