Ubiquitin Conjugating Enzyme E2 C Rabbit mAb
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, IHC-F, IP, ICC |
---|---|
Primary Accession | O00762 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Monoclonal Antibody |
Calculated MW | 19652 Da |
Gene ID | 11065 |
---|---|
Other Names | UBE2C |
Dilution | WB~~1/500-1/1000 IHC~~1/50-1/100 IF~~1/50-1/200 IP~~1/20 |
Format | Liquid |
Name | UBE2C |
---|---|
Synonyms | UBCH10 |
Function | Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit. |
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