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ROR1 Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, FC, E |
|---|---|
| Primary Accession | Q01973 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 104283 Da |
| Gene ID | 4919 |
|---|---|
| Other Names | Tyrosine-protein kinase transmembrane receptor ROR1, Neurotrophic tyrosine kinase, receptor-related 1, ROR1, NTRKR1 |
| Target/Specificity | This ROR1 antibody is generated from rabbits immunized with recombinant human ROR1 protein (aa region: 112 - 399). |
| Dilution | WB~~1:4000 IHC-P~~1:100 FC~~1:25 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ROR1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ROR1 |
|---|---|
| Synonyms | NTRKR1 |
| Function | Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo (PubMed:25029443). Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443, PubMed:27162350). In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells (PubMed:27162350). Via IGFBP5 ligand, forms a complex with ERBB2 to enhance CREB oncogenic signaling (PubMed:36949068). |
| Cellular Location | Membrane; Single- pass type I membrane protein. Cell projection, axon {ECO:0000250|UniProtKB:Q9Z139} |
| Tissue Location | Expressed strongly in human heart, lung and kidney, but weakly in the CNS. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm |
Provided below are standard protocols that you may find useful for product applications.
Background
ROR1 is a receptor protein tyrosine kinase whose cellular role has not been determined. It is a type I membrane protein and belongs to the ROR subfamily of cell surface receptors. Studies of a similar protein in mouse suggest that this protein may interact with another receptor protein tyrosine kinase and may be involved in skeletal and cardiac development.
References
Nomi, M., et al., Mol. Cell. Biol. 21(24):8329-8335 (2001).
Reddy, U.R., et al., Genomics 41(2):283-285 (1997).
Reddy, U.R., et al., Oncogene 13(7):1555-1559 (1996).
Masiakowski, P., et al., J. Biol. Chem. 267(36):26181-26190 (1992).
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